CoroPrevention trial
The main method of this project is the CoroPrevention Trial that allows us to prospectively evaluate the personalized prevention program in coronary heart disease (CHD) in a randomized fashion.
The actual trial can be separated into three subsequent blocks; risk stratification and randomization, actual prospective trial as well as data evaluation and dissemination.
CoroPrevention trial flow chart (in the picture) shows origin of CHD patients, design of the trial and evaluation and dissemination activities.
Clinical center selection and organization
Clinical centers were selected based on a survey on secondary prevention programs conducted by ESC. Furthermore, a wide European dimension was ensured. Therefore, the following countries were selected: Finland, Poland, Greece, Italy, Germany and Portugal.
12 000 screened patients in two years
For each selected country, we have set a target to screen 2000 CHD patients with the CoroPredict test during the two years dedicated for patient recruitment and randomize 170 high-risk patients in the three-year intervention comparing personalized care to standard care.
High risk patients will be identified based on biomarker screening
We expect that 15-20% of all consented patients will fulfill the high risk criteria of the CoroPredict biomarker score. Therefore 1000 patients will be randomized both in the usual care and personalized prevention program arm of the trial.
List of randomized clinical trial (RCT) sites
| # | RCT site | PI |
|---|---|---|
| 1 | Oulu University Hospital | Janne Hukkanen |
| 2 | Kuopio University Hospital | Juha Hartikainen |
| 3 | North Karelia Central Hospital, Joensuu | Tuomas Rissanen |
| 4 |
Helsinki University Hospital |
Juha Sinisalo |
| 4 | Mehiläinen Hospital, Helsinki | Kristina Hotakainen |
| 5 | University of Bialystok | Karol Kamiński |
| 6 | Nicolaus Copernicus University, Bydgoszcz | Aldona Kubica |
| 7 | Institute of Cardiology, Warsaw | Rafał Dąbrowski |
| 8 | University of Lublin | Andrzej Wysokiński |
| 9 | Medical University of Silesia, Katowice | Zbigniew Gąsior |
| 10 | Jagiellonian University Medical College | Piotr Jankowski |
| 11 | University Hospital Leipzig | Ulric Laufs |
| 12 | Heidelberg University | Winfried März |
| 13 | The Rechts der Isar Hospital, Munich | Martin Halle |
| 14 | University of Verona | Giovanni Targher |
| 15 | University Hospital Turin | Gaetano De Ferrari |
| 16 | University Hospital Genova | Italo Porto |
| 17 | Casilino Hospital Rome | Roberta Della Bona |
| 18 | Hospital Santa Maria / Medical School-University of Lisbon | Ana Abreu |
| 18 | Hospital do Espírito Santo, Évora, Lisbon | Lino Patricio |
| 19 | Konstantopoulio General Hospital | Patsilinakos Sotrios |
| 20 | Sismanoglion General Hospital | Dimitrios Sionis |
| 20 | Hellenic Red Cross General Hospital | Apostolos Katsivas / Lazaris Efstathios |